Cis,cis-1,3,5-Triaminocyclohexane explained

cis,cis-1,3,5-Triaminocyclohexane is an organic compound with the formula (CH₂CHNH₂)₃. It is a triamine. Of the many isomers possible for triaminocyclohexane, the cis,cis-1,3,5-derivative has attracted attention because it is a common tripodal ligand, abbreviated as tach. It is a colorless oil. It is a popular tridentate ligand in coordination chemistry.

It is prepared from the triscarbamate of cyclohexane. The latter is generated via the Curtius rearrangement starting from cyclohexanetricarboxylic acid.^[1]

Related ligands

• Tris(aminomethyl)ethane, another tripodal triamine (CH₃C(CH₂NH₂]₃)

References

1. 10.1016/0960-894X(96)00110-2. An improved synthesis of cis,cis-1,3,5-triaminocyclohexane. Synthesis of novel hexadentate ligand derivatives for the preparation of gallium radiopharmaceuticals. Bioorganic & Medicinal Chemistry Letters. 6. 7. 807–810. 1996. Bowen. Tom. Planalp. Roy P.. Brechbiel. Martin W..