Ciclotizolam Explained

Ciclotizolam[1] (WE-973) is a drug which is a thienotriazolodiazepine derivative. It is a partial agonist for the benzodiazepine site of the GABAA receptor, with similar binding affinity to related compounds like brotizolam, but a low efficacy.[2] [3]

See also

References

  1. DE Patent 2445430
  2. Weber KH, Kuhn FJ, Böke-Kuhn K, Lehr E, Danneberg PB, Hommer D, Paul SM, Skolnick P . Pharmacological and neurochemical properties of 1,4-diazepines with two annelated heterocycles ('hetrazepines') . European Journal of Pharmacology . 109 . 1 . 19–31 . February 1985 . 2986988 . 10.1016/0014-2999(85)90535-7.
  3. Ikeda M, Weber KH, Bechtel WD, Malatynska E, Yamamura HI . Relative efficacies of 1,4-diazepines on GABA-stimulated chloride influx in rat brain vesicles . Life Sciences . 45 . 4 . 349–58 . 1989 . 2569655 . 10.1016/0024-3205(89)90145-8.

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