Chromone Explained

Chromone (or 1,4-benzopyrone) is a derivative of benzopyran with a substituted keto group on the pyran ring. It is an isomer of coumarin.

Derivatives of chromone are collectively known as chromones. Most, though not all, chromones are also phenylpropanoids.

Examples

• 6,7-dimethoxy-2,3-dihydrochromone has been isolated from Sarcolobus globosus.
• Eucryphin, a chromone rhamnoside, can be isolated from the bark of Eucryphia cordifolia.^[1]
• Cromolyn (disodium cromoglicate) was found to inhibit antigen challenge as well as stress induced symptoms.^[2] Cromoglicate is used as a mast cell stabilizer in allergic rhinitis, asthma and allergic conjunctivitis.
• Nedocromil sodium was found to have a somewhat longer half-life than cromolyn; however, production was discontinued in the US in 2008.
• Xanthone with a second aromatic ring.

See also

• Coumarin – a structural isomer
• Furanochromones

References

1. Eucryphin, a new chromone rhamnoside from the bark of Eucryphia cordifolia. R. Tschesche, S. Delhvi, S. Sepulveda and E. Breitmaier, Phytochemistry, Volume 18, Issue 5, 1979, pages 867–869,
2. HOWELL, J.B. & ALTOUNYAN, R.E. (1967). A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma. Lancet, 2, 539–542. Abstract

External links

• – "4-chromone"
  • Synthesis at organic-chemistry.org