Chondroitin ABC lyase explained
| chondroitin-sulfate-ABC endolyase |
| Ec Number: | 4.2.2.20 |
| Cas Number: | 9024-13-9 |
| chondroitin-sulfate-ABC exolyase |
| Ec Number: | 4.2.2.21 |
| Cas Number: | 9024-13-9 |
Chondroitin ABC lyase (chondroitinase, chondroitin ABC eliminase, chondroitinase ABC) is an enzyme with systematic name chondroitin ABC lyase.[1] [2] This enzyme catalyses the following chemical reaction
Eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl or 1,3-alpha-L-iduronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups
This enzyme acts on chondroitin 4-sulfate, chondroitin 6-sulfate and dermatan sulfate.
Uses
Following a spinal cord injury, this enzyme can be used to erode scar tissue that can interfere with regeneration.[3]
Notes and References
- Yamagata T, Saito H, Habuchi O, Suzuki S . Purification and properties of bacterial chondroitinases and chondrosulfatases . The Journal of Biological Chemistry . 243 . 7 . 1523–35 . April 1968 . 10.1016/S0021-9258(18)93574-X . 5647268 . free .
- Saito H, Yamagata T, Suzuki S . Enzymatic methods for the determination of small quantities of isomeric chondroitin sulfates . The Journal of Biological Chemistry . 243 . 7 . 1536–42 . April 1968 . 10.1016/S0021-9258(18)93575-1 . 4231029 . free .
- Bartus K, James ND, Didangelos A, Bosch KD, Verhaagen J, Yáñez-Muñoz RJ, Rogers JH, Schneider BL, Muir EM, Bradbury EJ . Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury . The Journal of Neuroscience. 34 . 14 . 4822–36 . April 2014 . 24695702 . 3972714 . 10.1523/JNEUROSCI.4369-13.2014 .
