Chondroitin 4-sulfotransferase explained

chondroitin 4-sulfotransferase
Ec Number:	2.8.2.5
Cas Number:	83589-04-2
Go Code:	0047756

In enzymology, a chondroitin 4-sulfotransferase is an enzyme that catalyzes the chemical reaction

3'-phosphoadenosine-5'-phosphosulfate + chondroitin

\rightleftharpoons adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and chondroitin, whereas its two products are adenosine 3',5'-bisphosphate and chondroitin 4'-sulfate.

This enzyme belongs to the family of transferases, to be specific, the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase. This enzyme is also called chondroitin sulfotransferase. This enzyme participates in 3 metabolic pathways: chondroitin sulfate biosynthesis, sulfur metabolism, and the biosynthesis of glycan structures.

References

• Habuchi O, Miyashita N . 1982 . Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage . Biochim. Biophys. Acta . 717 . 414 - 21 . 6957247 . 3 . 10.1016/0304-4165(82)90282-3.
• Nakanishi Y, Otsu K, Suzuki S . 1983 . Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine . FEBS Lett. . 151 . 15 - 8 . 6130977 . 10.1016/0014-5793(83)80332-9 . 1 . free .
• Nakanishi Y, Shimizu M, Otsu K, Kato S, Tsuji M, Suzuki S . 1981 . A terminal 6-sulfotransferase catalyzing a synthesis of N-acetylgalactosamine 4,6-bissulfate residue at the nonreducing terminal position of chondroitin sulfate . J. Biol. Chem. . 256 . 5443 - 9 . 6787041 . 11 .
• Suzuki S . Strominger JL . 1960 . Enzymatic sulfation of mucopolysaccharides in hen oviduct. I Transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to mucopolysaccharides . J. Biol. Chem. . 235 . 257 - 266 . 13835879.
• Suzuki S . Strominger JL . 1960 . Enzymatic sulfation of mucopolysaccharides in hen oviduct. II Mechanism of the reaction studied with oligosaccharides and monosaccharides as acceptors . J. Biol. Chem. . 235 . 267 - 273 . 13835880.
• Suzuki S . Strominger JL . 1960 . Enzymatic sulfation of mucopolysaccharides in hen oviduct. III Mechanism of sulfation of chondroitin and chondroitin sulfate A . J. Biol. Chem. . 235 . 274 - 276 . 13835881.