Choloyl-CoA hydrolase explained

Choloyl-CoA hydrolase
Ec Number:	3.1.2.27

The enzyme choloyl-CoA hydrolase (EC 3.1.2.27) catalyzes the reaction

choloyl-CoA + H₂O

\rightleftharpoons cholate + CoA

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name is choloyl-CoA hydrolase. Other names in common use include PTE-2 (ambiguous), choloyl-coenzyme A thioesterase, chenodeoxycholoyl-coenzyme A thioesterase, and peroxisomal acyl-CoA thioesterase 2.

References

• Hunt MC, Solaas K, Kase BF, Alexson SE . 2002 . Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism . J. Biol. Chem. . 277 . 1128 - 38 . 11673457 . 10.1074/jbc.M106458200 . 2 . free .
• Solaas K, Sletta RJ, Soreide O, Kase BF . 2000 . Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver . Scand. J. Clin. Lab. Invest. . 60 . 91 - 102 . 10817395 . 10.1080/00365510050184903 . 2 .
• Russell DW . 2003 . The enzymes, regulation, and genetics of bile acid synthesis . Annu. Rev. Biochem. . 72 . 137 - 74 . 12543708 . 10.1146/annurev.biochem.72.121801.161712 .