Taurochenodeoxycholic acid explained

Taurochenodeoxycholic acid is a bile acid formed in the liver of most species, including humans, by conjugation of chenodeoxycholic acid with taurine.^[1] It is secreted into bile and then into the intestine.^[2] It is usually ionized at physiologic pH. However, although it can be crystallized as the sodium salt.

It acts as a detergent to solubilize fats in the small intestine and is itself absorbed by active transport in the terminal ileum.^[3]

It is used as a cholagogue and choleretic.

See also

• Tauroursodeoxycholic acid, an epimer
• See article about Taurodeoxycholic acid as an interferent in Perfluorooctanesulfonic acid (PFOS) mass spectrometry analysis.

Notes and References

1. Hofmann AF . The continuing importance of bile acids in liver and intestinal disease . Arch. Intern. Med. . 159 . 22 . 2647–58 . 1999 . 10597755 . 10.1001/archinte.159.22.2647. 21211064 .
2. Perez de la Cruz Moreno M, Oth M, Deferme S, Lammert F, Tack J, Dressman J, Augustijns P . Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum . The Journal of Pharmacy and Pharmacology . 58 . 8 . 1079–89 . August 2006 . 16872555 . 10.1211/jpp.58.8.0009 . free .
3. Carey MC, Small DM . Micelle formation by bile salts. Physical-chemical and thermodynamic considerations . Archives of Internal Medicine . 130 . 4 . 506–27 . October 1972 . 4562149 . 10.1001/archinte.1972.03650040040005.