Cetiedil Explained

Cetiedil is a vasodilator and an anti-sickling agent.[1]

Synthesis

The Clemmensen reduction of 3-thienylcyclohexyl-glycolic acid, CID:11064522 (1) gives cyclohexyl(thiophen-3-yl)acetic acid [16199-74-9] (2). Esterification of the sodium salt of the resulting acid with 1-(2-chloroethyl)azepane [2205-31-4] (3) produces cetiedil (4).

Notes and References

  1. Alavi JB . Sickle cell anemia. Pathophysiology and treatment . The Medical Clinics of North America . 68 . 3 . 545–56 . May 1984 . 6205230 . 10.1016/s0025-7125(16)31115-4 .

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