Cerato-platanin explained

Symbol:	Cerato-platanin
Cerato-platanin
Pfam:	PF07249
Pfam Clan:	CL0199
Interpro:	IPR010829

In molecular biology, the cerato-platanin family of proteins includes the phytotoxin cerato-platanin (CP) produced by the Ascomycete Ceratocystis platani. CP homologs are also found in both the Ascomycota and the Basidiomycota branches of Dikarya.^[1] This toxin causes the severe plant disease: canker stain. This protein occurs in the cell wall of the fungus and is involved in the host-pathogen interaction and induces both cell necrosis and phytoalexin synthesis which is one of the first plant defense-related events. CP, like other fungal surface proteins, is able to self-assemble in vitro.^[2] CP is a 120 amino acid protein, containing 40% hydrophobic residues. It is one of the rare examples of protein in which contains a Hopf link.^[3] The link is formed by covalent loops - the pieces of protein backbone closed by two disulphide bonds^[4] (formed out of four cysteine residues). The N-terminal region of CP is very similar to cerato-ulmin, a phytotoxic protein produced by the Ophiostoma species belonging to the hydrophobin family, which also self-assembles.^[5]

Notes and References

1. Chen . Hongxin . Kovalchuk . Andriy . Keriö . Susanna . Asiegbu . Fred O. . Distribution and bioinformatic analysis of the cerato-platanin protein family in Dikarya . Mycologia . 20 January 2017 . 105 . 2013 . 1479–1488 . 10.3852/13-115 . 23928425 . 23984426 .
2. Sbrana F, Bongini L, Cappugi G, Fanelli D, Guarino A, Pazzagli L, Scala A, Vassalli M, Zoppi C, Tiribilli B . Atomic force microscopy images suggest aggregation mechanism in cerato-platanin . Eur. Biophys. J. . 36 . 7 . 727–32 . September 2007 . 17431609 . 10.1007/s00249-007-0159-x . 11585837 .
3. Dabrowski-Tumanski. Pawel. Sulkowska. Joanna I.. 2017-03-28. Topological knots and links in proteins. Proceedings of the National Academy of Sciences. en. 114. 13. 3415–3420. 10.1073/pnas.1615862114. 0027-8424. 28280100. 5380043. 2017PNAS..114.3415D . free.
4. Pazzagli L, Cappugi G, Manao G, Camici G, Santini A, Scala A . Purification, characterization, and amino acid sequence of cerato-platanin, a new phytotoxic protein from Ceratocystis fimbriata f. sp. platani . J. Biol. Chem. . 274 . 35 . 24959–64 . August 1999 . 10455173 . 10.1074/jbc.274.35.24959. free .
5. Carresi L, Pantera B, Zoppi C, Cappugi G, Oliveira AL, Pertinhez TA, Spisni A, Scala A, Pazzagli L . Cerato-platanin, a phytotoxic protein from Ceratocystis fimbriata: expression in Pichia pastoris, purification and characterization . Protein Expr. Purif. . 49 . 2 . 159–67 . October 2006 . 16931046 . 10.1016/j.pep.2006.07.006 .