Cefradine Explained

Cefradine (INN) or cephradine (BAN) is a first generation cephalosporin antibiotic.[1]

Indications

Formulations

Cefradine is distributed in the form of capsules containing 250 mg or 500 mg, as a syrup containing 250 mg/5 ml, or in vials for injection containing 500 mg or 1 g.

It is not approved by the FDA for use in the United States.

Synthesis

Birch reduction of D-α-phenylglycine led to diene (2). This was N-protected using tert-butoxycarbonylazide and activated for amide formation via the mixed anhydride method using isobutylchloroformate to give 3. Mixed anhydride 3 reacted readily with 7-aminodesacetoxycephalosporanic acid to give, after deblocking, cephradine (5).

Production names

The antibiotic is produced under many brand names across the world.[3]

See also

Notes and References

  1. Book: British National Formulary. 2003. British Medical Association. London. 45.
  2. [Penicillin]
  3. Web site: Cefradine. 5 May 2016.