Cepharanthine Explained

Iupac Name:(14S,27R)-22,33-dimethoxy-13,28-dimethyl-2,5,7,20-tetraoxa-13,28-diazaoctacyclo[25.6.2.2<sup>16,19</sup>.1<sup>3,10</sup>.1<sup>21,25</sup>.0<sup>4,8</sup>.0<sup>31,35</sup>.0<sup>14,39</sup>]nonatriaconta-1(33),3(39),4(8),9,16(38),17,19(37),21,23,25(36),31,34-dodecaene
Cas Number:481-49-2
Unii:7592YJ0J6T
Atc Prefix:none
Pubchem:10206
Chembl:449782
Chemspiderid:9791
Synonyms:Cepharantin, O-Methylcepharanoline
C:37
H:38
N:2
O:6
Smiles:CN1CCC2=CC3=C(C4=C2[C@@H]1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)C[C@@H]7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
Stdinchi:1S/C37H38N2O6/c1-38-13-11-24-18-31(41-4)33-20-27(24)28(38)16-23-7-10-30(40-3)32(17-23)44-26-8-5-22(6-9-26)15-29-35-25(12-14-39(29)2)19-34-36(37(35)45-33)43-21-42-34/h5-10,17-20,28-29H,11-16,21H2,1-4H3/t28-,29+/m1/s1
Stdinchikey:YVPXVXANRNDGTA-WDYNHAJCSA-N

Cepharanthine is an antiinflammatory and antineoplastic compound isolated from Stephania.[1] Due to these modalities, it has been shown effective against HTLV in lab research. [2] Additionally, it has successfully been used to treat a diverse range of medical conditions, including radiation-induced leukopenia, idiopathic thrombocytopenic purpura, alopecia areata, alopecia pityrodes, venomous snakebites, xerostomia, sarcoidosis, refractory anemia and various cancer-related conditions. No safety issues have been observed with CEP, and side effects are very rarely reported. [3]

Notes and References

  1. Huang H, Hu G, Wang C, Xu H, Chen X, Qian A . 7186762 . Cepharanthine, an alkaloid from Stephania cepharantha Hayata, inhibits the inflammatory response in the RAW264.7 cell and mouse models . Inflammation . 37 . 1 . 235–46 . February 2014 . 24045962 . 10.1007/s10753-013-9734-8 .
  2. Toyama M, Hamasaki T, Uto T, Aoyama H, Okamoto M, Hashmoto Y, Baba M . Synergistic inhibition of HTLV-1-infected cell proliferation by combination of cepharanthine and a tetramethylnaphthalene derivative . Anticancer Research . 32 . 7 . 2639–45 . July 2012 . 22753721 .
  3. Rogosnitzky M, Danks R . Therapeutic potential of the biscoclaurine alkaloid, cepharanthine, for a range of clinical conditions . Pharmacological Reports . 2011 . 63 . 2 . 337–47 . 21602589 . 10.1016/S1734-1140(11)70500-X .