Cathepsin X Explained

Cathepsin X
Ec Number:	3.4.18.1
Cas Number:	37217-21-3

Cathepsin X (cathepsin B2, cysteine-type carboxypeptidase, cathepsin IV, cathepsin Z, acid carboxypeptidase, lysosomal carboxypeptidase B) is an enzyme.^{[1] [2] [3] [4] [5] [6]} This enzyme catalyses the following chemical reaction

Release of C-terminal amino acid residues with broad specificity, but lacks action on C-terminal proline. Shows weak endopeptidase activity

Cathepsin X is a cysteine cathepsin, a lysosomal cysteine peptidase of family C1 (papain family).

See also

• Cathepsin Z

Notes and References

1. Nägler DK, Zhang R, Tam W, Sulea T, Purisima EO, Ménard R . Human cathepsin X: A cysteine protease with unique carboxypeptidase activity . Biochemistry . 38 . 39 . 12648–54 . September 1999 . 10504234 . 10.1021/bi991371z .
2. Nägler DK, Ménard R . Human cathepsin X: a novel cysteine protease of the papain family with a very short proregion and unique insertions . FEBS Letters . 434 . 1–2 . 135–9 . August 1998 . 9738465 . 10.1016/S0014-5793(98)00964-8 . free .
3. Santamaría I, Velasco G, Pendás AM, Fueyo A, López-Otín C . Cathepsin Z, a novel human cysteine proteinase with a short propeptide domain and a unique chromosomal location . The Journal of Biological Chemistry . 273 . 27 . 16816–23 . July 1998 . 9642240 . 10.1074/jbc.273.27.16816 . free .
4. McDonald JK, Ellis S . On the substrate specificity of cathepsins B1 and B2 including a new fluorogenic substrate for cathepsin B1 . Life Sciences . 17 . 8 . 1269–76 . October 1975 . 577 . 10.1016/0024-3205(75)90137-x .
5. Otto K, Riesenkönig H . Improved purification of cathepsin B1 and cathepsin B2 . Biochimica et Biophysica Acta (BBA) - Protein Structure . 379 . 2 . 462–75 . February 1975 . 1122298 . 10.1016/0005-2795(75)90153-1 .
6. Ninjoor V, Taylor SL, Tappel AL . Purification and characterization of rat liver lysosomal cathepsin B2 . Biochimica et Biophysica Acta (BBA) - Enzymology . 370 . 1 . 308–21 . November 1974 . 4429705 . 10.1016/0005-2744(74)90055-2 .