Cathepsin W Explained

Cathepsin W is a protein that in humans is encoded by the CTSW gene.^{[1] [2] [3]}

The protein encoded by this gene, a member of the peptidase C1 family of cysteine cathepsins, is a cysteine protease cathepsin that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the cell membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2.^[3]

Further reading

• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Meinhardt C, Peitz U, Treiber G . Identification of a novel isoform predominantly expressed in gastric tissue and a triple-base pair polymorphism of the cathepsin W gene. . Biochem. Biophys. Res. Commun. . 321 . 4 . 975–80 . 2004 . 15358123 . 10.1016/j.bbrc.2004.07.056 . etal.
• Zhang Z, Henzel WJ . Signal peptide prediction based on analysis of experimentally verified cleavage sites. . Protein Sci. . 13 . 10 . 2819–24 . 2005 . 15340161 . 10.1110/ps.04682504 . 2286551.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Buhling F, Kellner U, Guenther D . Characterization of novel anti-cathepsin W antibodies and cellular distribution of cathepsin W in the gastrointestinal tract. . Biol. Chem. . 383 . 7–8 . 1285–9 . 2003 . 12437118 . 10.1515/BC.2002.144 . 23389714 . etal.
• Wex T, Bühling F, Wex H . Human cathepsin W, a cysteine protease predominantly expressed in NK cells, is mainly localized in the endoplasmic reticulum. . J. Immunol. . 167 . 4 . 2172–8 . 2001 . 11490002 . 10.4049/jimmunol.167.4.2172. etal. free .
• Book: Wex T, Levy B, Wex H, Brömme D . Human Cathepsins W and F form a New Subgroup of Cathepsins that is Evolutionary Separated from the Cathepsin B- and L-Like Cysteine Proteases . Cellular Peptidases in Immune Functions and Diseases 2 . Advances in Experimental Medicine and Biology . 477 . 271–80 . 2000 . 10849754 . 10.1007/0-306-46826-3_29 . 0-306-46383-0 .
• Brinkworth RI, Tort JF, Brindley PJ, Dalton JP . Phylogenetic relationships and theoretical model of human cathepsin W (lymphopain), a cysteine proteinase from cytotoxic T lymphocytes. . Int. J. Biochem. Cell Biol. . 32 . 3 . 373–84 . 2000 . 10716634 . 10.1016/S1357-2725(99)00129-6 .
• Wex T, Levy B, Wex H, Brömme D . Human cathepsins F and W: A new subgroup of cathepsins. . Biochem. Biophys. Res. Commun. . 259 . 2 . 401–7 . 1999 . 10362521 . 10.1006/bbrc.1999.0700 .
• Brown J, Matutes E, Singleton A . Lymphopain, a cytotoxic T and natural killer cell-associated cysteine proteinase. . Leukemia . 12 . 11 . 1771–81 . 1998 . 9823953 . 10.1038/sj.leu.2401164 . etal. 31373986 .

External links

• The MEROPS online database for peptidases and their inhibitors: C01.037

Notes and References

1. Linnevers C, Smeekens SP, Brömme D . Human cathepsin W, a putative cysteine protease predominantly expressed in CD8+ T-lymphocytes . FEBS Lett . 405 . 3 . 253–9 . May 1997 . 9108299 . 10.1016/S0014-5793(97)00118-X. 45420314 .
2. Wex T, Levy B, Smeekens SP, Ansorge S, Desnick RJ, Bromme D . Genomic structure, chromosomal localization, and expression of human cathepsin W . Biochem Biophys Res Commun . 248 . 2 . 255–61 . Aug 1998 . 9675123 . 10.1006/bbrc.1998.8954 .
3. Web site: Entrez Gene: CTSW cathepsin W.