Catalase-peroxidase explained

Catalase-peroxidase
Ec Number:	1.11.1.21

Catalase-peroxidase (katG (gene)) is an enzyme with systematic name donor:hydrogen-peroxide oxidoreductase.^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

1. donor + H₂O₂ oxidized donor + 2 H₂O
2. 2 H₂O₂ O₂ + 2 H₂O

This enzyme is a strong catalase with H₂O₂ as donor which releases O₂.

Notes and References

1. Loewen PC, Triggs BL, George CS, Hrabarchuk BE . Genetic mapping of katG, a locus that affects synthesis of the bifunctional catalase-peroxidase hydroperoxidase I in Escherichia coli . Journal of Bacteriology . 162 . 2 . 661–7 . May 1985 . 10.1128/JB.162.2.661-667.1985 . 3886630 . 218901 .
2. Hochman A, Goldberg I . Purification and characterization of a catalase-peroxidase and a typical catalase from the bacterium Klebsiella pneumoniae . Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology . 1077 . 3 . 299–307 . April 1991 . 2029529 . 10.1016/0167-4838(91)90544-a .
3. Fraaije MW, Roubroeks HP, Hagen WR, Van Berkel WJ . Purification and characterization of an intracellular catalase-peroxidase from Penicillium simplicissimum . European Journal of Biochemistry . 235 . 1–2 . 192–8 . January 1996 . 8631329 . 10.1111/j.1432-1033.1996.00192.x . 10.1.1.317.1785 .
4. Bertrand T, Eady NA, Jones JN, Nagy JM, Jamart-Grégoire B, Raven EL, Brown KA . Crystal structure of Mycobacterium tuberculosis catalase-peroxidase . The Journal of Biological Chemistry . 279 . 37 . 38991–9 . September 2004 . 15231843 . 10.1074/jbc.M402382200 . free .
5. Vlasits J, Jakopitsch C, Bernroitner M, Zamocky M, Furtmüller PG, Obinger C . Mechanisms of catalase activity of heme peroxidases . Archives of Biochemistry and Biophysics . 500 . 1 . 74–81 . August 2010 . 20434429 . 10.1016/j.abb.2010.04.018 .