Caspase-10 Explained

Caspase-10
Ec Number:	3.4.22.63
Cas Number:	189088-85-5

Caspase-10 (FLICE2, Mch4, CASP-10, ICE-like apoptotic protease 4, apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1beta-converting enzyme 2) is an enzyme.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp!Gly

Caspase-10 is an initiator caspase, as are caspase-2 (EC 3.4.22.55), caspase-8 (EC 3.4.22.61) and caspase-9 (EC 3.4.22.62).

Notes and References

1. Howard Y. Chang . Chang HY, Yang X . Proteases for cell suicide: functions and regulation of caspases . Microbiology and Molecular Biology Reviews . 64 . 4 . 821–46 . December 2000 . 11104820 . 99015 . 10.1128/mmbr.64.4.821-846.2000 .
2. Fischer U, Stroh C, Schulze-Osthoff K . Unique and overlapping substrate specificities of caspase-8 and caspase-10 . Oncogene . 25 . 1 . 152–9 . January 2006 . 16186808 . 10.1038/sj.onc.1209015 . free .
3. Shikama Y, Yamada M, Miyashita T . Caspase-8 and caspase-10 activate NF-kappaB through RIP, NIK and IKKalpha kinases . European Journal of Immunology . 33 . 7 . 1998–2006 . July 2003 . 12884866 . 10.1002/eji.200324013 . free .
4. Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS . Activation of caspases-8 and -10 by FLIP(L) . The Biochemical Journal . 382 . Pt 2 . 651–7 . September 2004 . 15209560 . 1133822 . 10.1042/bj20040809 .