Carotenoid isomerooxygenase explained

Carotenoid isomerooxygenase
Ec Number:	1.13.11.65

Carotenoid isomerooxygenase (ninaB (gene)) is an enzyme with systematic name zeaxanthin:oxygen 15,15'-oxidoreductase (bond-cleaving, cis-isomerizing).^[1] This enzyme catalyses the following chemical reaction

zeaxanthin + O₂

\rightleftharpoons

(3R)-11-cis-3-hydroxyretinal + (3R)-all-trans-3-hydroxyretinal

The enzyme from the moth Galleria mellonella and the fruit fly Drosophila melanogaster takes part in the synthesis of retinal .

Notes and References

Oberhauser V, Voolstra O, Bangert A, von Lintig J, Vogt K . NinaB combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptide . Proceedings of the National Academy of Sciences of the United States of America . 105 . 48 . 19000–5 . December 2008 . 19020100 . 2596218 . 10.1073/pnas.0807805105 . 2008PNAS..10519000O . free .