Carotenoid-9',10'-cleaving dioxygenase explained

Carotenoid-9',10'-cleaving dioxygenase
Ec Number:1.13.11.71

Carotenoid-9',10'-cleaving dioxygenase (BCO2 (gene), beta-carotene 9',10'-monooxygenase (misleading)) is an enzyme with systematic name all-trans-beta-carotene:O2 oxidoreductase (9',10'-cleaving).[1] [2] This enzyme catalyses the following chemical reaction

all-trans-beta-carotene + O2

\rightleftharpoons

all-trans-10'-apo-beta-carotenal + beta-ionone

Carotenoid-9',10'-cleaving dioxygenase contains Fe2+.

Notes and References

  1. Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, von Lintig J . Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A . The Journal of Biological Chemistry . 276 . 17 . 14110–6 . April 2001 . 11278918 . 10.1074/jbc.M011510200 . free .
  2. Lindqvist A, He YG, Andersson S . Cell type-specific expression of beta-carotene 9',10'-monooxygenase in human tissues . The Journal of Histochemistry and Cytochemistry . 53 . 11 . 1403–12 . November 2005 . 15983114 . 10.1369/jhc.5A6705.2005 . free .