Carlactone synthase explained

Carlactone synthase
Ec Number:	1.13.11.69

Carlactone synthase (CCD8 (gene), MAX4 (gene), NCED8 (gene)) is an enzyme with systematic name 9-cis-10'-apo-beta-carotenal:O2 oxidoreductase (14,15-cleaving, carlactone-forming).^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

9-cis-10'-apo-beta-carotenal + 2 O₂

\rightleftharpoons carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal

Carlactone synthase contains Fe²⁺.

Notes and References

1. Sorefan K, Booker J, Haurogné K, Goussot M, Bainbridge K, Foo E, Chatfield S, Ward S, Beveridge C, Rameau C, Leyser O . MAX4 and RMS1 are orthologous dioxygenase-like genes that regulate shoot branching in Arabidopsis and pea . Genes & Development . 17 . 12 . 1469–74 . June 2003 . 12815068 . 196077 . 10.1101/gad.256603 .
2. Schwartz SH, Qin X, Loewen MC . The biochemical characterization of two carotenoid cleavage enzymes from Arabidopsis indicates that a carotenoid-derived compound inhibits lateral branching . The Journal of Biological Chemistry . 279 . 45 . 46940–5 . November 2004 . 15342640 . 10.1074/jbc.M409004200 . free .
3. Alder A, Jamil M, Marzorati M, Bruno M, Vermathen M, Bigler P, Ghisla S, Bouwmeester H, Beyer P, Al-Babili S . The path from β-carotene to carlactone, a strigolactone-like plant hormone . Science . 335 . 6074 . 1348–51 . March 2012 . 22422982 . 10.1126/science.1218094 . 29137583 .