Carboxyamidotriazole Explained

Carboxyamidotriazole is a calcium channel blocker that blocks voltage-gated and ligand-gated calcium channels and has been investigated as an anti-cancer drug in vitro.[1] [2]

Notes and References

  1. 9816048. 1995. Figg. W. D.. Cole. K. A.. Reed. E.. Steinberg. S. M.. Piscitelli. S. C.. Davis. P. A.. Soltis. M. J.. Jacob. J.. Boudoulas. S.. Goldspiel. B.. Pharmacokinetics of orally administered carboxyamido-triazole, an inhibitor of calcium-mediated signal transduction. Clinical Cancer Research . 1. 8. 797–803.
  2. 30338034. 6188062. 2018. Bonnefond. M. L.. Florent. R.. Lenoir. S.. Lambert. B.. Abeilard. E.. Giffard. F.. Louis. M. H.. Elie. N.. Briand. M.. Vivien. D.. Poulain. L.. Gauduchon. P.. n'Diaye. M.. Inhibition of store-operated channels by carboxyamidotriazole sensitizes ovarian carcinoma cells to anti-BCLXL strategies through MCL-1 down-regulation. Oncotarget. 9. 74. 33896–33911. 10.18632/oncotarget.26084.

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