Carbon-monoxide dehydrogenase (ferredoxin) explained

carbon-monoxide dehydrogenase (ferredoxin)
Ec Number:	1.2.7.4
Go Code:	0043885

In enzymology, a carbon-monoxide dehydrogenase (ferredoxin) is an enzyme that catalyzes the chemical reaction

CO + H₂O + oxidized ferredoxin

\rightleftharpoons CO₂ + reduced ferredoxin

The three substrates of this enzyme are CO, H₂O, and oxidized ferredoxin, whereas its two products are CO₂ and reduced ferredoxin.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with an iron-sulfur protein as acceptor. The systematic name of this enzyme class is carbon-monoxide,water:ferredoxin oxidoreductase.

References

• Meyer O, Schlegel HG . 1980 . Carbon monoxide:methylene blue oxidoreductase from Pseudomonas carboxydovorans . Journal of Bacteriology . 141 . 74 - 80 . 7354006 . 1 . 10.1128/jb.141.1.74-80.1980 . 293533 .
• Ragsdale SW, Clark JE, Ljungdahl LG, Lundie LL, Drake HL . 1983 . Properties of purified carbon monoxide dehydrogenase from Clostridium thermoaceticum, a nickel, iron-sulfur protein . Journal of Biological Chemistry . 258 . 2364 - 9 . 6687389 . 4 . 10.1016/S0021-9258(18)32932-6 . free .
• Doukov TI, Iverson TM, Seravalli J, Ragsdale SW, Drennan CL . 2002 . A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase . Science . 298 . 567 - 72 . 12386327 . 10.1126/science.1075843 . 5593 . 2002Sci...298..567D .