Carbazole 1,9a-dioxygenase explained

Carbazole 1,9a-dioxygenase
Ec Number:	1.14.12.22

Carbazole 1,9a-dioxygenase (CARDO) is an enzyme with systematic name 9H-carbazole,NAD(P)H:oxygen oxidoreductase (2,3-hydroxylating).^{[1] [2]} This enzyme catalyses the following chemical reaction

9H-carbazole + NAD(P)H + H⁺ + O₂

\rightleftharpoons 2'-aminobiphenyl-2,3-diol + NAD(P)⁺

Carbazole 1,9a-dioxygenase catalyses the first reaction in the pathway of carbazole degradation.

Notes and References

1. Nam JW, Nojiri H, Noguchi H, Uchimura H, Yoshida T, Habe H, Yamane H, Omori T . Purification and characterization of carbazole 1,9a-dioxygenase, a three-component dioxygenase system of Pseudomonas resinovorans strain CA10 . Applied and Environmental Microbiology . 68 . 12 . 5882–90 . December 2002 . 12450807 . 134387 . 10.1128/aem.68.12.5882-5890.2002 . 2002ApEnM..68.5882N .
2. Gai Z, Wang X, Liu X, Tai C, Tang H, He X, Wu G, Deng Z, Xu P . The genes coding for the conversion of carbazole to catechol are flanked by IS6100 elements in Sphingomonas sp. strain XLDN2-5 . PLOS ONE . 5 . 4 . e10018 . April 2010 . 20368802 . 2848856 . 10.1371/journal.pone.0010018 . 2010PLoSO...510018G . free .