Carbamate kinase explained
| carbamate kinase |
| Ec Number: | 2.7.2.2 |
| Cas Number: | 9026-69-1 |
| Go Code: | 0008804 |
In enzymology, a carbamate kinase is an enzyme that catalyzes the chemical reaction
ATP + NH3 + CO2
ADP + carbamoyl phosphate
The 3 substrates of this enzyme are ATP, NH3, and CO2, whereas its two products are ADP and carbamoyl phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. The systematic name of this enzyme class is ATP:carbamate phosphotransferase. Other names in common use include CKase, carbamoyl phosphokinase, and carbamyl phosphokinase. This enzyme participates in 4 metabolic pathways: purine metabolism, glutamate metabolism, arginine and proline metabolism, and nitrogen metabolism.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes,, and .
References
- Bishop SH, Grisolia S . 1966 . Crystalline carbamate kinase . Biochim. Biophys. Acta . 118 . 211 - 5 . 4959296 . 1 . 10.1016/s0926-6593(66)80163-7 .
- Davis RH . 1965 . Carbamyl phosphate synthesis in Neurospora crassa. I. Preliminary characterization of arginine-specific carbamyl phosphokinase . Biochim. Biophys. Acta . 107 . 44 - 53 . 5857367 . 1 . 10.1016/0304-4165(65)90387-9. 2027.42/31986 . free .
- Glasziou KT . 1956 . The metabolism of arginine in Serratia marcescens. II Carbamyladenosine diphosphate phosphoferase . Aust. J. Biol. Sci. . Sci. . 2 . 253 - 262 . 10.1071/BI9560253 . free .
- Jones ME, Spector L, Lipmann F . 1955 . Carbamyl phosphate, the carbamyl donor in enzymatic citrulline synthesis . J. Am. Chem. Soc. . 77 . 3 . 819 - 820 . 10.1021/ja01608a101 .
- Srivenugopal KS, Adiga PR . 1981 . Enzymic conversion of agmatine to putrescine in Lathyrus sativus seedlings. Purification and properties of a multifunctional enzyme (putrescine synthase) . J. Biol. Chem. . 256 . 9532 - 41 . 6895223 . 18 .
