CNO (gene) explained

Protein cappuccino homolog is a protein that in humans is encoded by the CNO gene.^{[1] [2] [3]}

This intronless gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and is a model for Hermansky–Pudlak syndrome. The encoded protein may play a role in intracellular vesicular trafficking.^[3]

Interactions

CNO (gene) has been shown to interact with BLOC1S2^[4] and PLDN.^[4]

Further reading

• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . etal.
• Starcevic M, Dell'Angelica EC . Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1). . J. Biol. Chem. . 279 . 27 . 28393–401 . 2004 . 15102850 . 10.1074/jbc.M402513200 . free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Li W, Zhang Q, Oiso N . Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). . Nat. Genet. . 35 . 1 . 84–9 . 2003 . 12923531 . 10.1038/ng1229 . 2860733 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . etal. 2002PNAS...9916899M . free .
• Moriyama K, Bonifacino JS . Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles. . Traffic . 3 . 9 . 666–77 . 2003 . 12191018 . 10.1034/j.1600-0854.2002.30908.x . 29888859 . free .

Notes and References

1. Ciciotte SL, Gwynn B, Moriyama K, Huizing M, Gahl WA, Bonifacino JS, Peters LL . Cappuccino, a mouse model of Hermansky-Pudlak syndrome, encodes a novel protein that is part of the pallidin-muted complex (BLOC-1) . Blood . 101 . 11 . 4402–7 . May 2003 . 12576321 . 10.1182/blood-2003-01-0020 . free .
2. Gwynn B, Ciciotte SL, Hunter SJ, Washburn LL, Smith RS, Andersen SG, Swank RT, Dell'Angelica EC, Bonifacino JS, Eicher EM, Peters LL . Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism . Blood . 96 . 13 . 4227–35 . Dec 2000 . 11110696 . 10.1182/blood.V96.13.4227.
3. Web site: Entrez Gene: CNO cappuccino homolog (mouse).
4. Starcevic . Marta . Dell'Angelica Esteban C . Jul 2004 . Identification of snapin and three novel proteins (BLOS1, BLOS2, and BLOS3/reduced pigmentation) as subunits of biogenesis of lysosome-related organelles complex-1 (BLOC-1) . J. Biol. Chem. . 279 . 27 . 28393–401 . 0021-9258. 15102850 . 10.1074/jbc.M402513200 . free .