Cannabidiolic acid explained

Cannabidiolic acid (CBDA), is a cannabinoid produced in cannabis plants.[1] It is most abundant in the glandular trichomes on the female seedless flowers or more accurately infructescence often colloquially referred to as buds or flowers.[2]

Biosynthesis

Cannabidiolic acid is a natural product sesquiterpene biosynthesized in cannabis via Cannabidiolic acid synthase from the conjugation of olivetolic acid and cannabigerolic acid.[3]

Decarboxylation

CBDA is the chemical precursor to cannabidiol (CBD). Through the process of decarboxylation cannabidiol is derived through a loss of one carbon and two oxygen atoms acetyl from the 1 position of the benzoic acid ring.

Notes and References

  1. Takeda. Shuso. 2013. [Medicinal chemistry and pharmacology focused on cannabidiol, a major component of the fiber-type cannabis]. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan. 133. 10. 1093–1101. 10.1248/yakushi.13-00196. 1347-5231. 24088353. free.
  2. Livingston. Samuel J.. Quilichini. Teagen D.. Booth. Judith K.. Wong. Darren C. J.. Rensing. Kim H.. Laflamme‐Yonkman. Jessica. Castellarin. Simone D.. Bohlmann. Joerg. Page. Jonathan E.. Samuels. A. Lacey. Cannabis glandular trichomes alter morphology and metabolite content during flower maturation. The Plant Journal. 2020. 101. 1 . en. 37–56. 10.1111/tpj.14516. 31469934. 1365-313X. free.
  3. Web site: Cannabidiolic acid. PubChem. pubchem.ncbi.nlm.nih.gov. en. 2019-12-23.

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