Candidapepsin Explained

Candidapepsin
Ec Number:	3.4.23.24
Cas Number:	69458-91-9

Candidapepsin (Candida albicans aspartic proteinase, Candida albicans carboxyl proteinase, Candida albicans secretory acid proteinase, Candida olea acid proteinase, Candida aspartic proteinase, Candida olea aspartic proteinase) is an enzyme.^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction

Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu¹⁵-Tyr, Tyr¹⁶-Leu and Phe²⁴-Phe of insulin B chain. Activates trypsinogen, and degrades keratin

This endopeptidase is present in yeast Candida albicans.

Notes and References

1. Remold H, Fasold H, Staib F . Purification and characterization of a proteolytic enzyme from Candida albicans . Biochimica et Biophysica Acta (BBA) - Enzymology . 167 . 2 . 399–406 . October 1968 . 5729955 . 10.1016/0005-2744(68)90219-2 .
2. Rüchel R . Properties of a purified proteinase from the yeast Candida albicans . Biochimica et Biophysica Acta (BBA) - Enzymology . 659 . 1 . 99–113 . May 1981 . 7018586 . 10.1016/0005-2744(81)90274-6 .
3. Negi M, Tsuboi R, Matsui T, Ogawa H . Isolation and characterization of proteinase from Candida albicans: substrate specificity . The Journal of Investigative Dermatology . 83 . 1 . 32–6 . July 1984 . 6203988 . 10.1111/1523-1747.ep12261656 . free .
4. Lott TJ, Page LS, Boiron P, Benson J, Reiss E . Nucleotide sequence of the Candida albicans aspartyl proteinase gene . Nucleic Acids Research . 17 . 4 . 1779 . February 1989 . 2646602 . 331855 . 10.1093/nar/17.4.1779 .