Canals of Hering explained

Canals of Hering
Latin:	ductulus bilifer

The canals of Hering, or intrahepatic bile ductules, are part of the outflow system of exocrine bile product from the liver. Liver stem cells are hypothesized to inhabit the canals.^{[1] [2]}

Structure

They are found between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule.^{[3] [4]}

Histology

Histologically, the cells of the ductule are described as simple cuboidal epithelium, lined partially by cholangiocytes and hepatocytes. They may not be readily visible but can be differentially stained by cytokeratins CK19 and CK7.

Clinical relevance

The canals of Hering are destroyed early in primary biliary cholangitis and may be primary sites of scarring in methotrexate toxicity. Research has indicated the presence of intraorgan stem cells of the liver that can proliferate in disease states, so-called oval cells.^[5] Liver stem cells are theorized to originate in the niches of the canals.^{[6] [1]}

History

They are named for Ewald Hering.^[7]

Notes and References

1. Oliva . Joan . French . Barbara A. . Qing . X. . French . Samuel W. . The identification of stem cells in human liver diseases and hepatocellular carcinoma . Experimental and Molecular Pathology . Elsevier BV . 88 . 3 . 2010 . 0014-4800 . 10.1016/j.yexmp.2010.01.003 . 331–340. 3593713 .
2. De Alwis . Nimantha . Hudson . Gavin . Burt . Alastair D. . Day . Christopher P. . Chinnery . Patrick F. . Human liver stem cells originate from the canals of hering . Hepatology . Ovid Technologies (Wolters Kluwer Health) . 50 . 3 . 2009-07-07 . 0270-9139 . 10.1002/hep.23160 . 992–993. free .
3. Ross, M.H. & Pawlina, W. 2003. Histology: A Text and Atlas, 4th Edition. Lippincott Williams & Wilkins, Philadelphia.
4. Gartner, L.P. & Hiatt, J.L. 2000. Color Atlas of Histology, 3rd Edition. Lippincott Williams & Wilkins, Philadelphia.
5. Saxena, R. & Theise, N. 2004. Canals of Hering: Recent Insights and Current Knowledge, Semin Liver Dis 24: 43-48.
6. Kordes . Claus . Häussinger . Dieter . Hepatic stem cell niches . Journal of Clinical Investigation . American Society for Clinical Investigation . 123 . 5 . 2013-05-01 . 0021-9738 . 10.1172/jci66027 . 1874–1880. 3638908 .
7. Hering E. Uber den Bau der Wirbelthierleber. Archiv für mikroskopische Anatomie 1867;3:88–118