Calyculin Explained

Calyculins are natural products originally isolated from the marine sponge Discodermia calyx.[1] Calyculins have proven to be strong serine/threonine protein phosphatase inhibitors and based on this property, calyculins might be potential tumor-promoting agents.

A laboratory synthesis of calyculin A has been reported.[2]

Notes and References

  1. Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin. Suganuma M, Fujiki H, Furuya-Suguri H, Yoshizawa S, Yasumoto S, Kato Y, Fusetani N, Sugimura T. Cancer Res.. 1990. 50. 12. 3521–3525. 2160320.
  2. Tanimoto . Norihiko . Gerritz . Samuel W. . Sawabe . Akiyoshi . Noda . Takeshi . Filla . Sandra A. . Masamune . Satoru . 1994-03-17 . Synthese von natürlich vorkommendem (−)‐Calyculin A . Angewandte Chemie . en . 106 . 6 . 674–677 . 10.1002/ange.19941060611 . 0044-8249.

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