Calphostin Explained
The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides.[1] [2] The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity.[3]
|
| Calpohostin | R1 | R2 |
| Calphostin A | Bz | Bz |
| Calphostin B | Bz | H |
| Calphostin C | Bz | 4-(HO)Bz |
| Calphostin D | H | H |
| Calphostin I | 4-(HO)Bz | 4-(HO)Bz | |
Calphostin C
See main article: Calphostin C.
Calphostin C is a potent inhibitor of protein kinase C (PKC).
Notes and References
- J. Antibiot. . 1989 . 42 . 1470–1474 . Kobayashi, E . Ando, K . Nakano, H . Iida, T . Ohno, H . Morimoto, M . Tamaoki, T . 2478514 . Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities . 10 . 10.7164/antibiotics.42.1470. free .
- J. Antibiot. . 1989 . 42 . 1475–1481 . Iida, T . Kobayashi, E . Yoshida, M . Sano, H . 2478515 . Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures . 10 . 10.7164/antibiotics.42.1475. free .
- http://www.biomol-europe.com/Online_Catalog/Online_Catalog/Products/Product_Detail/38/?categoryId=57&productId=433&mid=75 Calphostin C (UCN-1028C)
