Calmegin Explained

Calmegin, also known as CLGN, is a protein which in humans is encoded by the CLGN gene.^[1] Calmegin is also present in other animals including mice.^[2]

Function

Calmegin is a testis-specific endoplasmic reticulum chaperone protein. CLGN may play a role in spermatogeneisis and infertility.^[1]

Further reading

• Watanabe D, Yamada K, Nishina Y . Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development . J. Biol. Chem. . 269 . 10 . 7744–7749 . 1994 . 10.1016/S0021-9258(17)37349-0 . 8126001 . etal. free .
• Ikawa M, Wada I, Kominami K . The putative chaperone calmegin is required for sperm fertility . Nature . 387 . 6633 . 607–611 . 1997 . 9177349 . 10.1038/42484 . 1997Natur.387..607I . 4347203 . etal.
• Tanaka H, Ikawa M, Tsuchida J . Cloning and characterization of the human Calmegin gene encoding putative testis-specific chaperone . Gene . 204 . 1–2 . 159–163 . 1998 . 9434179 . 10.1016/S0378-1119(97)00537-4 . etal.
• Yoshinaga K, Tanii I, Toshimori K . Molecular chaperone calmegin localization to the endoplasmic reticulum of meiotic and post-meiotic germ cells in the mouse testis . Arch. Histol. Cytol. . 62 . 3 . 283–293 . 1999 . 10495883 . 10.1679/aohc.62.283 . free .
• Ikawa M, Nakanishi T, Yamada S . Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility . Dev. Biol. . 240 . 1 . 254–261 . 2002 . 11784061 . 10.1006/dbio.2001.0462 . etal. free .
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Gerhard DS, Wagner L, Feingold EA . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928. etal.
• Rual JF, Venkatesan K, Hao T . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 . etal.
• Kim DH, Shim JS, Kwon HJ . Coordinated transcriptional regulation of calmegin,a testis-specific molecular chaperon, by histone deacetylase and CpG methyltransferase . . 37 . 5 . 492–496 . 2005 . 16264275 . 10.1038/emm.2005.61. free .
• Olsen JV, Blagoev B, Gnad F . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–648 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . etal. free .

Notes and References

1. Web site: Entrez Gene: CLGN calmegin.
2. Watanabe D, Yamada K, Nishina Y, Tajima Y, Koshimizu U, Nagata A, Nishimune Y . Molecular cloning of a novel Ca(2+)-binding protein (calmegin) specifically expressed during male meiotic germ cell development . J. Biol. Chem. . 269 . 10 . 7744–7749 . March 1994 . 10.1016/S0021-9258(17)37349-0 . 8126001 . free .