Calicivirin Explained

Calicivirin
Ec Number:	3.4.22.66

Calicivirin (Camberwell virus processing peptidase, Chiba virus processing peptidase, Norwalk virus processing peptidase, Southampton virus processing peptidase, norovirus virus processing peptidase, calicivirus trypsin-like cysteine protease, calicivirus TCP, calicivirus 3C-like protease, calicivirus endopeptidase, rabbit hemorrhagic disease virus 3C endopeptidase) is an enzyme.^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

Endopeptidase with a preference for cleavage when the P1 position is occupied by Glu- and the P1- position is occupied by Gly-

Viruses that are members of the genus Norovirus (family Caliciviridae) are a major cause of epidemic acute viral gastroenteritis.

Notes and References

1. Book: Calicivirus endopeptidases . Handbook of Proteolytic Enzymes . Meyers G, Rossi C, Thiel HJ . 2004 . 1380–1382 . Barrett AJ, Rawlings ND, Woessner JF . 2nd . Elsevier . London .
2. Wirblich C, Sibilia M, Boniotti MB, Rossi C, Thiel HJ, Meyers G . 3C-like protease of rabbit hemorrhagic disease virus: identification of cleavage sites in the ORF1 polyprotein and analysis of cleavage specificity . Journal of Virology . 69 . 11 . 7159–68 . November 1995 . 7474137 . 189637 .
3. Martín Alonso JM, Casais R, Boga JA, Parra F . Processing of rabbit hemorrhagic disease virus polyprotein . Journal of Virology . 70 . 2 . 1261–5 . February 1996 . 8551592 . 189940 .
4. Liu B, Clarke IN, Lambden PR . Polyprotein processing in Southampton virus: identification of 3C-like protease cleavage sites by in vitro mutagenesis . Journal of Virology . 70 . 4 . 2605–10 . April 1996 . 8642693 . 190109 .
5. Liu BL, Viljoen GJ, Clarke IN, Lambden PR . Identification of further proteolytic cleavage sites in the Southampton calicivirus polyprotein by expression of the viral protease in E. coli . The Journal of General Virology . 80 (Pt 2) . 2 . 291–6 . February 1999 . 10073687 . 10.1099/0022-1317-80-2-291 . free .