CAd3-ZEBOV explained
cAd3-ZEBOV (also known as the NIAID/GSK Ebola vaccine or cAd3-EBO Z) was an experimental vaccine for two ebolaviruses, Ebola virus and Sudan virus, developed by scientists at GlaxoSmithKline (GSK) and tested by National Institute of Allergy and Infectious Disease (NIAID).[1] This vaccine is derived from a chimpanzee adenovirus, Chimp Adenovirus type 3 (ChAd3), genetically engineered to express glycoproteins from the Zaire and Sudan species of ebolavirus to provoke an immune response against them. Simultaneous phase 1 trials of this vaccine commenced in September 2014, being administered to volunteers in Oxford and Bethesda.[2] During October the vaccine is being administered to a further group of volunteers in Mali. If this phase is completed successfully, the vaccine will be fast tracked for use in the Ebola virus epidemic in West Africa. In preparation for this, GSK is preparing a stockpile of 10,000 doses.[3] [4]
First British trial
Following ten Americans who received the vaccine in a trial, Ruth Atkins (born 1966)[5] of Oxfordshire, a former nurse with the British National Health Service, was the first British volunteer to receive the experimental vaccine (on September 17, 2014) in a vaccine trial run by Oxford University researchers and funded by the Wellcome Trust and the UK government. This variant was only designed to protect against Ebola virus and not Sudan virus.[6]
See also
Further reading
- Choi WY, Hong KJ, Hong JE, Lee WJ . January 2015 . Progress of vaccine and drug development for Ebola preparedness . Clinical and Experimental Vaccine Research . 4 . 1 . 11–6 . 10.7774/cevr.2015.4.1.11 . 4313103 . 25648233.
- 6 . De Santis O, Audran R, Pothin E, Warpelin-Decrausaz L, Vallotton L, Wuerzner G, Cochet C, Estoppey D, Steiner-Monard V, Lonchampt S, Thierry AC, Mayor C, Bailer RT, Mbaya OT, Zhou Y, Ploquin A, Sullivan NJ, Graham BS, Roman F, De Ryck I, Ballou WR, Kieny MP, Moorthy V, Spertini F, Genton B . March 2016 . Safety and immunogenicity of a chimpanzee adenovirus-vectored Ebola vaccine in healthy adults: a randomised, double-blind, placebo-controlled, dose-finding, phase 1/2a study . live . The Lancet. Infectious Diseases . 16 . 3 . 311–20 . 10.1016/S1473-3099(15)00486-7 . 26725450 . https://web.archive.org/web/20220311093302/https://serval.unil.ch/resource/serval:BIB_1B0E90763307.P001/REF.pdf . 2022-03-11 . 2019-12-13 . free.
Notes and References
- Pavot V . December 2016 . Ebola virus vaccines: Where do we stand? . Clinical Immunology . 173 . 44–49 . 10.1016/j.clim.2016.10.016 . 27910805.
- News: 2 October 2014 . Experimental Ebola Vaccine Processed in Maryland . . Associated Press.
- News: 17 September 2014 . First British volunteer injected with trial Ebola vaccine in Oxford . live . https://web.archive.org/web/20140917194333/http://www.theguardian.com/society/2014/sep/17/ruth-atkins-first-british-volunteer-injected-trial-ebola-vaccine-oxford . 17 September 2014 . 17 September 2014 . Guardian.
- News: 16 September 2014 . An Ebola vaccine was given to 10 volunteers, and there are 'no red flags' yet . live . https://web.archive.org/web/20200220193142/https://www.washingtonpost.com/news/to-your-health/wp/2014/09/16/an-ebola-vaccine-was-given-to-10-volunteers-and-there-are-no-red-flags-yet/ . 20 February 2020 . 17 September 2014 . Washington Post.
- Web site: 17 September 2014 . First volunteer receives new Ebola vaccine in UK trial . live . https://web.archive.org/web/20200425000209/http://www.ox.ac.uk/news/2014-09-17-first-volunteer-receives-new-ebola-vaccine-uk-trial . 2020-04-25 . 2014-10-15 . Oxford University.
- Web site: 17 September 2014 . First British volunteer injected with trial Ebola vaccine in Oxford . live . https://web.archive.org/web/20140917194333/http://www.theguardian.com/society/2014/sep/17/ruth-atkins-first-british-volunteer-injected-trial-ebola-vaccine-oxford . 17 September 2014 . 17 September 2014 . The Guardian.
