Butolame Explained

Butolame, also known as 17β-((4-hydroxybutyl)amino)estradiol, is a synthetic, steroidal estrogen and a 17β-aminoestrogen with anticoagulant effects that was first described in 1993 and was never marketed.[1] [2] [3]

Notes and References

  1. Book: Negwer M, Scharnow HG . Organic-chemical drugs and their synonyms: (an international survey). 2001. Wiley-VCH. 978-3-527-30247-5. 2352.
  2. Lemini C, Rubio-Póo C, Silva G, García-Mondragón J, Zavala E, Mendoza-Patiño N, Castro D, Cruz-Almanza R, Mandoki JJ . 6 . Anticoagulant and estrogenic effects of two new 17 beta-aminoestrogens, butolame [17 beta-(4-hydroxy-1-butylamino)-1,3,5(10)-estratrien-3-ol] and pentolame [17 beta-(5-hydroxy-1-pentylamino)-1,3,5(10)-estratrien-3-ol] . Steroids . 58 . 10 . 457–461 . October 1993 . 8256254 . 10.1016/0039-128x(93)90002-5 . 54381037 .
  3. Jaimez R, Cooney A, Jackson K, Lemus AE, Lemini C, Cárdenas M, García R, Silva G, Larrea F . 6 . In vivo estrogen bioactivities and in vitro estrogen receptor binding and transcriptional activities of anticoagulant synthetic 17beta-aminoestrogens . The Journal of Steroid Biochemistry and Molecular Biology . 73 . 1–2 . 59–66 . May 2000 . 10822025 . 10.1016/s0960-0760(00)00053-4 . 40211307 .

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