Butalamine Explained

Butalamine is a vasodilator.^[1]

Synthesis

The reaction of benzamidoxime (1) with chlorine and subsequent reaction with cyanamide (3) gives 5-amino-3-phenyl-1,2,4-oxadiazole (4).^{[2] [3] [4]} Base catalyzed alkylation with dibutylaminoethyl chloride (5) completes the synthesis of butalamine (6).

Notes and References

1. Sterne J . [Butalamine hydrochloride. A new vasoactive substance] . German . Fortschritte Der Medizin . 94 . 11 . 657–9 . April 1976 . 823083 .
2. Aron-samuel Jan Marcel Didier, (1965 to Jan Marcel).
3. Japan. Pat., 76 108 068, (1976); CA, 87, 5981b
4. Aron-Samuel Jan Marcel Didier, Sterne Jean Jacques, (1967 to).