Butaclamol Explained

Butaclamol (AY-23,028) is a type of antipsychotic which was never marketed.[1] Sold as the hydrochloride salt for use in research, the compound acts as a dopamine receptor antagonist.[2]

Chemistry

pKa = 7.15 (uncorrected for ionic strength)[3]

Notes and References

  1. Book: Dictionary of organic compounds - Google Books . 978-0-412-54090-5 . Buckingham J . 1985 . CRC Press .
  2. Hall DA, Strange PG . Evidence that antipsychotic drugs are inverse agonists at D2 dopamine receptors . British Journal of Pharmacology . 121 . 4 . 731–6 . June 1997 . 9208141 . 1564749 . 10.1038/sj.bjp.0701196 .
  3. Chrzanowski FA, McGrogan BA, Maryanoff BE . The pKa of butaclamol and the mode of butaclamol binding to central dopamine receptors . Journal of Medicinal Chemistry . 28 . 3 . 399–400 . March 1985 . 2579238 . 10.1021/jm00381a022 .

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