Bromisoval Explained

Bromisoval (INN), commonly known as bromovalerylurea, is a hypnotic and sedative of the bromoureide group discovered by Knoll in 1907 and patented in 1909.^[1] It is marketed over the counter in Asia under various trade names (such as Brovarin^[2]), usually in combination with nonsteroidal anti-inflammatory drugs.

Chronic use of bromisoval has been associated with bromine poisoning.^{[3] [4] [5] [6]}

Bromisoval can be prepared by bromination of isovaleric acid by the Hell-Volhard-Zelinsky reaction followed by reaction with urea.

See also

• Acecarbromal
• Carbromal
• Apronal

Notes and References

1. US . patent . 914518 . 1909-03-09 . Saam, E. . Knoll . 1907-01-28 . Alpha-halogen-isovaleryl-urea and process of making the same.
2. Web site: Bromisoval . International . Drugs.com .
3. Hashida . H. . Honda . T. . Morimoto . H. . Aibara . Y. . 市販鎮痛剤常用量の服用による慢性ブロム中毒の1例. A case of chronic bromvalerylurea intoxication due to habitual use of commercially available nonsteroidal anti-inflammatory drugs presenting an indefinite hyperchloremia . Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics . 38 . Japanese. 5 . 700–703 . 2001 . 11605223. 0300-9173. 10.3143/geriatrics.38.700 . pdf. free .
4. Kawakami . T. . Takiyama . Y. . Yanaka . I. . Taguchi . T. . Tanaka . Y. . Nishizawa . M. . Nakano . I. . Chronic bromvalerylurea intoxication: Dystonic posture and cerebellar ataxia due to nonsteroidal anti-inflammatory drug abuse . Internal Medicine . Tokyo, Japan . 37 . 9 . 788–791 . 1998 . 9804091 . 10.2169/internalmedicine.37.788. pdf. free .
5. Wang . Y. -T. . Yang . S. Y. . Wu . V. C. . Wu . K. D. . Fang . C. C. . Pseudohyperchloraemia due to bromvalerylurea abuse . 10.1093/ndt/gfh945 . Nephrology Dialysis Transplantation . 20 . 8 . 1767–1768 . 2005 . 15972320 . free .
6. Arai . A. . Sato . M. . Hozumi . I. . Matsubara . N. . Tanaka . K. . Soma . Y. . Adachi . T. . Tsuji . S. . Cerebellar Ataxia and Peripheral Neuropathy due to Chronic Bromvalerylurea Poisoning . Internal Medicine. Tokyo, Japan . 36 . 10 . 742–746 . 1997 . 9372340. 10.2169/internalmedicine.36.742. pdf. free .