Brensocatib Explained

Cas Number:1802148-05-5
Pubchem:118253852
Iuphar Ligand:9412
Drugbank:DB15638
Chemspiderid:67896269
Unii:25CG88L0BB
Kegg:D12120
Chembl:3900409
Synonyms:AZD7986; INS1007
Iupac Name:(2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
C:23
H:24
N:4
O:4
Smiles:CN1C2=C(C=CC(=C2)C3=CC=C(C=C3)C[C@@H](C#N)NC(=O)[C@@H]4CNCCCO4)OC1=O
Stdinchi:1S/C23H24N4O4/c1-27-19-12-17(7-8-20(19)31-23(27)29)16-5-3-15(4-6-16)11-18(13-24)26-22(28)21-14-25-9-2-10-30-21/h3-8,12,18,21,25H,2,9-11,14H2,1H3,(H,26,28)/t18-,21-/m0/s1
Stdinchikey:AEXFXNFMSAAELR-RXVVDRJESA-N

Brensocatib is an investigational new drug that is being evaluated to treat bronchiectasis.[1] It is a dipeptidyl-peptidase I (also known as cathepsin C) inhibitor.[2]

Notes and References

  1. Web site: Brensocatib - Insmed . AdisInsight . Springer Nature Switzerland AG .
  2. Chalmers JD, Usansky H, Rubino CM, Teper A, Fernandez C, Zou J, Mange KC . Pharmacokinetic/Pharmacodynamic Evaluation of the Dipeptidyl Peptidase 1 Inhibitor Brensocatib for Non-cystic Fibrosis Bronchiectasis . Clinical Pharmacokinetics . 61 . 10 . 1457–1469 . October 2022 . 35976570 . 9553789 . 10.1007/s40262-022-01147-w .