Brain-specific angiogenesis inhibitor 2 explained

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene.^{[1] [2]} It is a member of the adhesion-GPCR family of receptors.^[3]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.^[2]

Further reading

• Kreienkamp HJ, Zitzer H, Gundelfinger ED . The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. . J. Biol. Chem. . 275 . 42 . 32387–90 . 2000 . 10964907 . 10.1074/jbc.C000490200 . etal. free .
• Kee HJ, Koh JT, Kim MY . Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. . J. Cereb. Blood Flow Metab. . 22 . 9 . 1054–67 . 2002 . 12218411 . 10.1097/00004647-200209000-00003 . etal. free .
• Petersen HH, Hilpert J, Militz D . Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. . J. Cell Sci. . 116 . Pt 3 . 453–61 . 2003 . 12508107 . 10.1242/jcs.00243 . etal. free .
• Adkins JN, Varnum SM, Auberry KJ . Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. . Mol. Cell. Proteomics . 1 . 12 . 947–55 . 2003 . 12543931 . 10.1074/mcp.M200066-MCP200. etal. free .
• Nagaraja GM, Kandpal RP . Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. . Biochem. Biophys. Res. Commun. . 313 . 3 . 654–65 . 2004 . 14697242 . 10.1016/j.bbrc.2003.12.001 .
• Ota T, Suzuki Y, Nishikawa T . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . etal. free .
• Bjarnadóttir TK, Fredriksson R, Höglund PJ . The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. . Genomics . 84 . 1 . 23–33 . 2005 . 15203201 . 10.1016/j.ygeno.2003.12.004 . etal.

Notes and References

1. Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T . Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) . Cytogenet Cell Genet . 79 . 1–2 . 103–8 . Apr 1998 . 9533023 . 10.1159/000134693 .
2. Web site: Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2.
3. Book: Stacey, edited by Simon Yona, Martin. Adhesion-GPCRs : structure to function. 2010. Springer Science+Business Media. New York. 9781441979124.