Brain-specific angiogenesis inhibitor 1 explained

Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene.[1] It is a member of the adhesion-GPCR family of receptors.[2]

Function

Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas.[3]

Interactions

Brain-specific angiogenesis inhibitor 1 has been shown to interact with BAIAP3[4] and MAGI1.[5]

Further reading

Notes and References

  1. Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T . Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1) . Cytogenetics and Cell Genetics . 79 . 1–2 . 103–8 . Apr 1998 . 9533023 . 10.1159/000134693 .
  2. Book: Stacey M, Yona S . AdhesionGPCRs: Structure to Function (Advances in Experimental Medicine and Biology) . Springer . Berlin . 2011 . 978-1-4419-7912-4 .
  3. Web site: Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1.
  4. Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, Nakamura Y . Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1 . Biochemical and Biophysical Research Communications . 251 . 1 . 158–65 . Oct 1998 . 9790924 . 10.1006/bbrc.1998.9408 .
  5. Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T . Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1 . Biochemical and Biophysical Research Communications . 247 . 3 . 597–604 . Jun 1998 . 9647739 . 10.1006/bbrc.1998.8603 .