CDCA8 explained

Borealin is a protein that in humans is encoded by the CDCA8 gene.^{[1] [2] [3]}

Function

CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.^[4]

Interactions

CDCA8 has been shown to interact with INCENP,^[4] Survivin^{[2] [4]} and Aurora B kinase.^{[2] [4]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . Jan 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . Oct 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Sauer G, Körner R, Hanisch A, Ries A, Nigg EA, Silljé HH . Proteome analysis of the human mitotic spindle . Molecular & Cellular Proteomics . 4 . 1 . 35–43 . Jan 2005 . 15561729 . 10.1074/mcp.M400158-MCP200 . free .
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . Jan 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Vader G, Kauw JJ, Medema RH, Lens SM . Survivin mediates targeting of the chromosomal passenger complex to the centromere and midbody . EMBO Reports . 7 . 1 . 85–92 . Jan 2006 . 16239925 . 1369225 . 10.1038/sj.embor.7400562 .
• Noton EA, Colnaghi R, Tate S, Starck C, Carvalho A, Ko Ferrigno P, Wheatley SP . Molecular analysis of survivin isoforms: evidence that alternatively spliced variants do not play a role in mitosis . The Journal of Biological Chemistry . 281 . 2 . 1286–95 . Jan 2006 . 16291752 . 10.1074/jbc.M508773200 . free .
• Chang JL, Chen TH, Wang CF, Chiang YH, Huang YL, Wong FH, Chou CK, Chen CM . Borealin/Dasra B is a cell cycle-regulated chromosomal passenger protein and its nuclear accumulation is linked to poor prognosis for human gastric cancer . Experimental Cell Research . 312 . 7 . 962–73 . Apr 2006 . 16427043 . 10.1016/j.yexcr.2005.12.015 .
• Lens SM, Rodriguez JA, Vader G, Span SW, Giaccone G, Medema RH . Uncoupling the central spindle-associated function of the chromosomal passenger complex from its role at centromeres . Molecular Biology of the Cell . 17 . 4 . 1897–909 . Apr 2006 . 16436504 . 1415303 . 10.1091/mbc.E05-08-0727 .
• Rodriguez JA, Lens SM, Span SW, Vader G, Medema RH, Kruyt FA, Giaccone G . Subcellular localization and nucleocytoplasmic transport of the chromosomal passenger proteins before nuclear envelope breakdown . Oncogene . 25 . 35 . 4867–79 . Aug 2006 . 16547492 . 10.1038/sj.onc.1209499 . 27074707 .
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R . Phosphoproteome analysis of the human mitotic spindle . Proceedings of the National Academy of Sciences of the United States of America . 103 . 14 . 5391–6 . Apr 2006 . 16565220 . 1459365 . 10.1073/pnas.0507066103 . 2006PNAS..103.5391N . free .
• Klein UR, Nigg EA, Gruneberg U . Centromere targeting of the chromosomal passenger complex requires a ternary subcomplex of Borealin, Survivin, and the N-terminal domain of INCENP . Molecular Biology of the Cell . 17 . 6 . 2547–58 . Jun 2006 . 16571674 . 1474794 . 10.1091/mbc.E05-12-1133 .
• Kaur H, Stiff AC, Date DA, Taylor WR . Analysis of mitotic phosphorylation of borealin . BMC Cell Biology . 8 . 5 . 2007 . 17241471 . 1794407 . 10.1186/1471-2121-8-5 . free .
• Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y . Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis . Cancer Research . 67 . 9 . 4113–22 . May 2007 . 17483322 . 10.1158/0008-5472.CAN-06-4705 . free .

Notes and References

1. Walker MG . Drug target discovery by gene expression analysis: cell cycle genes . . 1 . 1 . 73–83 . May 2001 . 12188893 . 10.2174/1568009013334241 .
2. Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H . The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly . Cell . 118 . 2 . 187–202 . Jul 2004 . 15260989 . 10.1016/j.cell.2004.06.026 . free .
3. Web site: Entrez Gene: CDCA8 cell division cycle associated 8.
4. Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC . Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle . The Journal of Cell Biology . 166 . 2 . 179–91 . Jul 2004 . 15249581 . 10.1083/jcb.200404001 . 2172304.