Blood-group-substance endo-1,4-beta-galactosidase explained

Blood-group-substance endo-1,4-β-galactosidase
Ec Number:	3.2.1.102
Cas Number:	52720-51-1

Blood-group-substance endo-1,4-β-galactosidase (endo-β-galactosidase, blood-group-substance 1,4-β-D-galactanohydrolase) is an enzyme with systematic name blood-group-substance 4-β-D-galactanohydrolase.^{[1] [2] [3]} It catalyses endohydrolysis of (1→4)-β-D-galactosidic linkages in blood group A and B substances.

It hydrolyses the 1,4-β-D-galactosyl linkages adjacent to a 1,3-α-D-galactosyl or N-acetylgalactosaminyl residues and a 1,2-α-D-fucosyl residue.

Notes and References

1. Fukuda MN, Matsumura G . Endo-β-galactosidase of Escherichia freundii. Purification and endoglycosidic action on keratan sulfates, oligosaccharides, and blood group active glycoprotein . The Journal of Biological Chemistry . 251 . 20 . 6218–25 . October 1976 . 135762 .
2. Nakazawa K, Suzuki S . Purification of Keratan Sulfate-endogalactosidase and its action on keratan sulfates of different origin . The Journal of Biological Chemistry . 250 . 3 . 912–7 . February 1975 . 234443 .
3. Takasaki S, Kobata A . Purification and characterization of an endo-β-galactosidase produced by Diplococcus pneumoniae . The Journal of Biological Chemistry . 251 . 12 . 3603–9 . June 1976 . 6459 .