Blasticidin-S deaminase explained

blasticidin-S deaminase
Ec Number:	3.5.4.23
Cas Number:	54576-55-5
Go Code:	0047711

In enzymology, a blasticidin-S deaminase is an enzyme that catalyzes the chemical reaction

blasticidin S + H₂O

\rightleftharpoons deaminohydroxyblasticidin S + NH₃

Thus, the two substrates of this enzyme are blasticidin S and H₂O, whereas its two products are deaminohydroxyblasticidin S and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is blasticidin-S aminohydrolase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes and .

References

• Yamaguchi I, Shibata H, Seto H, Misato T . Tokyo . Isolation and purification of blasticidin S deaminase from Aspergillus terreus . J. Antibiot. . 7 - 14 . 236272 . 1 . 28 . January 1975 . 10.7164/antibiotics.28.7. free .