Bivatuzumab Explained
Bivatuzumab (previously BIWA 4) is a humanized monoclonal antibody against CD44 v6.[1] [2]
It is officially described as "immunoglobulin G1 (human-mouse monoclonal BIWA4 γ1-chain anti-human antigen CD44v6), disulfide with human-mouse monoclonal BIWA4 κ-chain, dimer".[3] Prior to 2002 it was described as targeting CD44 v8.[4]
It has been chemically linked to various radioisotopes for use in radiotherapy for, e.g. inoperable recurrent or metastatic head and neck cancer.[1]
It has also been linked to a cytotoxic drug mertansine to form bivatuzumab mertansine.
Notes and References
- Postema EJ, Börjesson PK, Buijs WC, Roos JC, Marres HA, Boerman OC, de Bree R, Lang M, Munzert G, van Dongen GA, Oyen WJ . 6 . Dosimetric analysis of radioimmunotherapy with 186Re-labeled bivatuzumab in patients with head and neck cancer . Journal of Nuclear Medicine . 44 . 10 . 1690–9 . October 2003 . 14530488 .
- Börjesson PK, Postema EJ, Roos JC, Colnot DR, Marres HA, van Schie MH, Stehle G, de Bree R, Snow GB, Oyen WJ, van Dongen GA . Phase I therapy study with (186)Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma . Clinical Cancer Research . 9 . 10 Pt 2 . 3961S–72S . September 2003 . 14506195 .
- Amendments to Previous Lists . WHO Drug Information . 16 . 3 . 2002 .
- Recommended INN: List 45 . WHO Drug Information . 15 . 1 . 2001 . 4 .