Bisphenol AF explained

Bisphenol AF (BPAF) is a fluorinated organic compound that is an analogue of bisphenol A in which the two methyl groups are replaced with trifluoromethyl groups. It exists as a white to light-gray powder.

Biological and Chemical Action

See also: endocrine disruptor.

Bisphenol AF is an endocrine disrupting chemical.^[1] Whereas BPA binds with human estrogen-related receptor gamma (ERR-γ), BPAF all but ignores ERR-γ. Instead, BPAF activates ERR-α and binds to and disables ERR-β.^[2]

The chemical shifts in ¹H, ¹³C and ¹⁹F NMR spectroscopy are given in the literature.^[3]

Applications

Bisphenol AF is used as a crosslinking agent for certain fluoroelastomers and as a monomer for polyimides, polyamides, polyesters, polycarbonate copolymers and other specialty polymers. Polymers containing Bisphenol AF are useful in specialties such as high-temperature composites and electronic materials. Industries include cosmetics, chemical manufacturing, production of metals and rubber. It can also be a plastic additive.^[4]

See also

• Bisphenol A
• Bisphenol S

Notes and References

1. Escrivá . Laura . Hanberg . Annika . Zilliacus . Johanna . Beronius . Anna . Assessment of the endocrine disrupting properties of Bisphenol AF according to the EU criteria and ECHA/EFSA guidance . EFSA Journal . September 2019 . 17 . EU‐FORA: Series 2 . e170914 . 10.2903/j.efsa.2019.e170914. 32626472 . 7015508 .
2. Web site: Janet Raloff: Another plastics ingredient raises safety concerns, Science News, June 5th, 2010; Vol.177 #12 (p. 14) . 2010-06-11 . 2012-09-27 . https://web.archive.org/web/20120927005453/http://www.sciencenews.org/view/generic/id/59113 . dead .
3. Hayasaka. Tatsuya. Katsuhara. Yutaka. Kume. Takashi. Yamazaki. Takashi. HF-mediated equilibrium between fluorinated ketones and the corresponding α-fluoroalcohols. Tetrahedron. 67. 12. 2215–2219. 10.1016/j.tet.2011.01.087. 2011.
4. Web site: Bisphenol AF . PubChem . National Library of Medicine . 20 January 2021.