Bisoctrizole Explained

Bisoctrizole (INN[1] /USAN,[2] marketed by BASF as Tinosorb M, by DSM Nutritional Products as Parsol Max , by Everlight Chemical as Eversorb M, and by MPI as Milestab 360, INCI methylene bis-benzotriazolyl tetramethylbutylphenol) is a phenolic benzotriazole that is added to sunscreens to absorb UV rays.[3] It is a broad-spectrum ultraviolet radiation absorber, absorbing UVB as well as UVA rays. It also reflects and scatters UV.

Bisoctrizole is what is termed is a hybrid UV absorber, which has been described as an organic UV filter produced in microfine organic particles (< 200 nm),[4] [5] like microfine zinc oxide and titanium dioxide. Where other organic UV absorbers dissolved in either the oily or aqueous phases, bisoctrizole dissolves poorly in both.

Hence, bisoctrizole is formulated in sunscreen preparations as a 50% suspension, the absorber added to the water phase, and mineral micropigments usually added to the oil phase. The bisoctrizole particles are stabilized by the surfactant decyl glucoside. The compound shows very little photodegradation, and has a stabilizing effect on other UV absorbers, octyl methoxycinnamate (octinoxate) in particular.

In primary research reports, bisoctrizole has been reported to minimally penetrate skin,[6] and has been described as lacking estrogenic effects in vitro.[7]

Bisoctrizole has not yet been approved by the U.S. Food and Drug Administration (FDA), but is approved in the EU and other parts of the world.[8] [9] [10]

External links

Notes and References

  1. WHO Staff . 2005 . Recommended International Nonproprietary Names: List 54, International Nonproprietary Names for Pharmaceutical Substances (INN) [Entry 'bisoctrizolum'] ]. dead . WHO Drug Information . 19 . 3 . https://web.archive.org/web/20091019164225/http://apps.who.int/medicinedocs/en/d/Js7918e/8.html . October 19, 2009 . July 5, 2022.
  2. Web site: National Library of Medicine Staff . July 5, 2022 . Bisoctrizole . July 5, 2022 . Chem.NLM.NIH.gov.
  3. Latha . MS . Martis . Jacintha . Shobha . V . Shinde . Rutuja Sham . Bangera . Sudhakar . Krishnankutty . Binny . Bellary . Shantala . Varughese . Sunoj . Rao . Prabhakar . Naveen Kumar . B.R. . January 2013 . Sunscreening Agents A Review . Journal of Clinical and Aesthetic Dermatology . 6 . 1 . 16–26 . 3543289 . 23320122.
  4. Web site: Ciba Staff . July 5, 2022 . TINOSORB® M, Broad-spectrum UV Filter for the Water Phase . July 5, 2022 . BASF.com.
  5. Herzog . B. . Mongiat . S. . Deshayes . C. . Neuhaus . M. . Sommer . K. . Mantler . A. . 2002 . In vivo and in vitro assessment of UVA protection by sunscreen formulations containing either butyl methoxy dibenzoyl methane, methylene bis-benzotriazolyl tetramethylbutylphenol, or microfine ZnO . International Journal of Cosmetic Science . 24 . 3 . 170–85 . 10.1046/j.1467-2494.2002.00137.x . 18498509 . 37553401.
  6. Mavon A, Miquel C, Lejeune O, Payre B, Moretto P . 2007 . In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen . Skin Pharmacol Physiol . 20 . 1 . 10–20 . 10.1159/000096167 . 17035717 . 22041398.
  7. Ashby J, Tinwell H, Plautz J, Twomey K, Lefevre PA . December 2001 . Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S . . 34 . 3 . 287–91 . 10.1006/rtph.2001.1511 . 11754532.
  8. Web site: Kapes, Beth . July 1, 2005 . Docs Rally for Better Sun Protection . registration . dead . https://web.archive.org/web/20071009095100/http://www.modernmedicine.com/modernmedicine/article/articleDetail.jsp?id=169626 . October 9, 2007 . July 5, 2022 . ModernMedicine.com.
  9. Web site: Eur-Lex.Europa.eu PDF . dead . https://web.archive.org/web/20080814155936/http://eur-lex.europa.eu/LexUriServ/site/en/consleg/1976/L/01976L0768-20060809-en.pdf . 2008-08-14 . 2007-08-19.
  10. https://web.archive.org/web/20070831075404/http://tga.gov.au/docs/pdf/argom_10.pdf Australian Regulatory Guidelines for OTC Medicines, Chapter 10.