Bisbiguanide Explained

Bisbiguanides are a class of chemically related compounds known for their bactericidal properties. Generally considered to be of the generic formula: R1 R2 N.C(:NR6)NH.C(:NH)NH.CH2 X--(CH2)3 NH.C(:NH)NH.C(:NR7)NR3 R4 V.[1] These compounds include the antiseptics chlorhexidine and alexidine. They are named for having two biguanide moieties, which themselves are named for having two guanide parts.[2]

Notes and References

  1. http://www.freepatentsonline.com/4670592.html Bisbiguanide compounds – Patent 4670592
  2. Tanzer JM, Slee AM, Kamay BA . Structural requirements of guanide, biguanide, and bisbiguanide agents for antiplaque activity . Antimicrob. Agents Chemother. . 12 . 6 . 721–9 . 1977 . 931371 . 10.1128/aac.12.6.721. 430011.