Bis-gamma-glutamylcystine reductase explained

bis-gamma-glutamylcystine reductase
Ec Number:	1.8.1.13
Cas Number:	117056-54-9
Go Code:	0047135

Bis-gamma-glutamylcystine reductase is an enzyme that catalyzes the chemical reaction

2 gamma-glutamylcysteine + NADP⁺

\rightleftharpoons bis-gamma-glutamylcystine + NADPH + H⁺

Thus, the two substrates of this enzyme are gamma-glutamylcysteine and nicotinamide adenine dinucleotide phosphate ion, whereas its 3 products are bis-gamma-glutamylcystine, nicotinamide adenine dinucleotide phosphate, and hydrogen ion.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is gamma-glutamylcysteine:NADP+ oxidoreductase. This enzyme is also called NADPH2:bis-gamma-glutamylcysteine oxidoreductase. This enzyme participates in glutathione metabolism.

References

• Sundquist AR, Fahey RC . 1988 . The novel disulfide reductase bis-gamma-glutamylcystine reductase and dihydrolipoamide dehydrogenase from Halobacterium halobium: purification by immobilized-metal-ion affinity chromatography and properties of the enzymes . J. Bacteriol. . 170 . 3459 - 67 . 3136140 . 8 . 211315 .
• Sundquist AR, Fahey RC . 1989 . The function of gamma-glutamylcysteine and bis-gamma-glutamylcystine reductase in Halobacterium halobium . J. Biol. Chem. . 264 . 719 - 25 . 2910862 . 2 .