Biotin—(methylmalonyl-CoA-carboxytransferase) ligase explained

Biotin—[methylmalonyl-CoA-carboxytransferase] ligase
Ec Number:	6.3.4.9
Cas Number:	37318-66-4
Go Code:	0004079

In enzymology, a biotin—[methylmalonyl-CoA-carboxytransferase] ligase is an enzyme that catalyzes the chemical reaction

ATP + biotin + apo-[methylmalonyl-CoA:pyruvate carboxytransferase]

\rightleftharpoons AMP + diphosphate + [methylmalonyl-CoA:pyruvate carboxytransferase]

The 3 substrates of this enzyme are ATP, biotin, and, whereas its 3 products are AMP, diphosphate, and .

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo[methylmalonyl-CoA:pyruvate carboxytransferase] ligase (AMP-forming). This enzyme participates in biotin metabolism.

References

• Lane MD, Young DL, Lynen F . 1964 . The enzymatic synthesis of holotranscarboxylase from apotranscarboxylase and (+)-biotin. I. Purification of the apoenzyme and synthetase; characteristics of the reaction . J. Biol. Chem. . 239 . 2858 - 2864 .