Biotin—(methylcrotonoyl-CoA-carboxylase) ligase explained

biotin-[methylcrotonoyl-CoA-carboxylase] ligase
Ec Number:6.3.4.11
Cas Number:37318-68-6
Go Code:0004078

In enzymology, a biotin-[methylcrotonoyl-CoA-carboxylase] ligase is an enzyme that catalyzes the chemical reaction

ATP + biotin + apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]

\rightleftharpoons

AMP + diphosphate + [3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)]

The 3 substrates of this enzyme are ATP, biotin, and, whereas its 3 products are AMP, diphosphate, and .

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is biotin:apo-[3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include biotin-[methylcrotonoyl-CoA-carboxylase] synthetase, biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase, beta-methylcrotonyl coenzyme A holocarboxylase synthetase, and holocarboxylase-synthetase. This enzyme participates in biotin metabolism.

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