Biotin—(acetyl-CoA-carboxylase) ligase explained

Biotin—[acetyl-CoA-carboxylase] ligase
Ec Number:	6.3.4.15
Cas Number:	37340-95-7
Go Code:	0004077

In enzymology, a biotin—[acetyl-CoA-carboxylase] ligase is an enzyme that catalyzes the chemical reaction

ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

\rightleftharpoons AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]

The 3 substrates of this enzyme are ATP, biotin, and apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)], whereas its 3 products are AMP, diphosphate, and acetyl-CoA:carbon-dioxide ligase (ADP-forming).

This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds.

This enzyme participates in biotin metabolism. This protein may use the morpheein model of allosteric regulation.^[1]

Nomenclature

The systematic name of this enzyme class is biotin:apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include:

• biotin-[acetyl-CoA carboxylase] synthetase,
• biotin-[acetyl coenzyme A carboxylase] synthetase,
• acetyl coenzyme A holocarboxylase synthetase,
• acetyl CoA holocarboxylase synthetase,
• biotin:apocarboxylase ligase,
• biotin holoenzyme synthetase,
• and HCS.

Further reading

• Landman AD, Darkshinamurti K . Acetyl-Coenzyme A carboxylase. Role of the prosthetic group in enzyme polymerization . Biochem. J. . 145 . 3 . 545–8 . March 1975 . 239688 . 1165255 . 10.1042/bj1450545.

Notes and References

1. Selwood T, Jaffe EK . Dynamic dissociating homo-oligomers and the control of protein function . Arch. Biochem. Biophys. . 519 . 2 . 131–43 . March 2012 . 22182754 . 3298769 . 10.1016/j.abb.2011.11.020 .