Alpha-1-microglobulin/bikunin precursor explained

Protein AMBP is a protein that in humans is encoded by the AMBP gene.^{[1] [2] [3]}

Interactions

Alpha-1-microglobulin/bikunin precursor has been shown to interact with CD79A.^{[4] [5]}

See also

• Inter-alpha-trypsin inhibitor
• Alpha-1-microglobulin

Further reading

• Akerström B, Lögdberg L, Berggård T, Osmark P, Lindqvist A . alpha(1)-Microglobulin: a yellow-brown lipocalin . Biochim. Biophys. Acta . 1482 . 1–2 . 172–84 . 2000 . 11058759 . 10.1016/S0167-4838(00)00157-6 .
• Kobayashi H, Suzuki M, Hirashima Y, Terao T . The protease inhibitor bikunin, a novel anti-metastatic agent . Biol. Chem. . 384 . 5 . 749–54 . 2003 . 12817471 . 10.1515/BC.2003.083 . 38608465 .
• Ekström B, Berggård I . Human alpha1-microglobulin. Purification procedure, chemical and physiochemical properties . J. Biol. Chem. . 252 . 22 . 8048–57 . 1977 . 10.1016/S0021-9258(17)40934-3 . 72071 . free .
• Escribano J, Lopex-Otin C, Hjerpe A, Grubb A, Mendez E . Location and characterization of the three carbohydrate prosthetic groups of human protein HC . FEBS Lett. . 266 . 1–2 . 167–70 . 1990 . 1694784 . 10.1016/0014-5793(90)81531-R . 36320110 . free .
• Diarra-Mehrpour M, Bourguignon J, Sesboüé R, Salier JP, Léveillard T, Martin JP . Structural analysis of the human inter-alpha-trypsin inhibitor light-chain gene . Eur. J. Biochem. . 191 . 1 . 131–9 . 1990 . 1696200 . 10.1111/j.1432-1033.1990.tb19102.x . free .
• Gebhard W, Schreitmüller T, Vetr H, Wachter E, Hochstrasser K . Complementary DNA and deduced amino acid sequences of procine alpha 1-microglobulin and bikunin . FEBS Lett. . 269 . 1 . 32–6 . 1990 . 1696914 . 10.1016/0014-5793(90)81112-2 . 84271910 . free .
• Falkenberg C, Grubb A, Akerström B . Isolation of rat serum alpha 1-microglobulin. Identification of a complex with alpha 1-inhibitor-3, a rat alpha 2-macroglobulin homologue . J. Biol. Chem. . 265 . 27 . 16150–7 . 1990 . 10.1016/S0021-9258(17)46201-6 . 1697852 . free .
• Nazimova SV, Akulenko IV, Zaĭtseva IV, Zaraĭskiĭ EI, Posiseeva LV . [Immunoenzyme analysis of placenta-specific alpha(1)-microglobulin in the blood serum in normal and pathological pregnancy] . Akush Ginekol (Mosk) . 7 . 70–2 . 1990 . 1700638 .
• Escribano J, Grubb A, Calero M, Méndez E . The protein HC chromophore is linked to the cysteine residue at position 34 of the polypeptide chain by a reduction-resistant bond and causes the charge heterogeneity of protein HC . J. Biol. Chem. . 266 . 24 . 15758–63 . 1991 . 10.1016/S0021-9258(18)98474-7 . 1714898 . free .
• Enghild JJ, Salvesen G, Hefta SA, Thøgersen IB, Rutherfurd S, Pizzo SV . Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor . J. Biol. Chem. . 266 . 2 . 747–51 . 1991 . 10.1016/S0021-9258(17)35235-3 . 1898736 . free .
• Reisinger P, Hochstrasser K, Albrecht GJ, Lempart K, Salier JP . Human inter-alpha-trypsin inhibitor: localization of the Kunitz-type domains in the N-terminal part of the molecule and their release by a trypsin-like proteinase . Biol. Chem. Hoppe-Seyler . 366 . 5 . 479–83 . 1985 . 2408638 . 10.1515/bchm3.1985.366.1.479 .
• Bourguignon J, Diarra-Mehrpour M, Sesboüé R, Frain M, Sala-Trepat JM, Martin JP, Salier JP . Human inter-alpha-trypsin-inhibitor: characterization and partial nucleotide sequencing of a light chain-encoding cDNA . Biochem. Biophys. Res. Commun. . 131 . 3 . 1146–53 . 1985 . 2413856 . 10.1016/0006-291X(85)90210-4 .
• Méndez E, Fernández-Luna JL, Grubb A, Leyva-Cobián F . Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis . Proc. Natl. Acad. Sci. U.S.A. . 83 . 5 . 1472–5 . 1986 . 2419908 . 323098 . 10.1073/pnas.83.5.1472 . 1986PNAS...83.1472M . free .
• Traboni C, Cortese R . Sequence of a full length cDNA coding for human protein HC (alpha 1 microglobulin) . Nucleic Acids Res. . 14 . 15 . 6340 . 1986 . 2428011 . 311643 . 10.1093/nar/14.15.6340 .
• Kaumeyer JF, Polazzi JO, Kotick MP . The mRNA for a proteinase inhibitor related to the HI-30 domain of inter-alpha-trypsin inhibitor also encodes alpha-1-microglobulin (protein HC) . Nucleic Acids Res. . 14 . 20 . 7839–50 . 1986 . 2430261 . 311818 . 10.1093/nar/14.20.7839 .
• Zaraĭskiĭ EI, Nazimova SV, Olefirenko GA, Pchelkina ZM, Petrunin DD, ((Tatarinov IuS)), Fuks BB . [Immunoenzyme analysis of placenta-specific alpha 1-microglobulin in the serum of blood donors] . Vopr. Med. Khim. . 35 . 5 . 130–2 . 1990 . 2482577 .
• Schreitmüller T, Hochstrasser K, Reisinger PW, Wachter E, Gebhard W . cDNA cloning of human inter-alpha-trypsin inhibitor discloses three different proteins . Biol. Chem. Hoppe-Seyler . 368 . 8 . 963–70 . 1987 . 3663330 . 10.1515/bchm3.1987.368.2.963 .
• Morii M, Travis J . The reactive site of human inter-alpha-trypsin inhibitor is in the amino-terminal half of the protein . Biol. Chem. Hoppe-Seyler . 366 . 1 . 19–21 . 1985 . 3890890 . 10.1515/bchm3.1985.366.1.19 .

External links

• The MEROPS online database for peptidases and their inhibitors: LI02-001

Notes and References

1. Vetr H, Gebhard W . Structure of the human alpha 1-microglobulin-bikunin gene . Biol. Chem. Hoppe-Seyler . 371 . 12 . 1185–96 . 1990 . 1708673 . 10.1515/bchm3.1990.371.2.1185 .
2. Salier JP, Simon D, Rouet P, Raguenez G, Muscatelli F, Gebhard W, Guenet JL, Mattei MG . Homologous chromosomal locations of the four genes for inter-alpha-inhibitor and pre-alpha-inhibitor family in human and mouse: assignment of the ancestral gene for the lipocalin superfamily . Genomics . 14 . 1 . 83–8 . Dec 1992 . 1385302 . 10.1016/S0888-7543(05)80287-3 .
3. Web site: Entrez Gene: AMBP alpha-1-microglobulin/bikunin precursor.
4. Grubb AO, López C, Tejler L, Mendez E . Isolation of human complex-forming glycoprotein, heterogeneous in charge (protein HC), and its IgA complex from plasma. Physiochemical and immunochemical properties, normal plasma concentration . J. Biol. Chem. . 258 . 23 . 14698–707 . December 1983 . 10.1016/S0021-9258(17)43919-6 . 6196366 . free .
5. Berggård T, Thelin N, Falkenberg C, Enghild JJ, Akerström B . Prothrombin, albumin and immunoglobulin A form covalent complexes with alpha1-microglobulin in human plasma . Eur. J. Biochem. . 245 . 3 . 676–83 . May 1997 . 9183005 . 10.1111/j.1432-1033.1997.00676.x . free .